Data from: Profile of and risk factors for post-stroke cognitive impairment in diverse ethno-regional groups

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dc.contributor.affiliationUniversity of New South Wales - Lo, Jessica W
dc.contributor.affiliationUniversity of New South Wales - Crawford, John D
dc.contributor.affiliation, - Desmond, David W
dc.contributor.affiliationCentre Hospitalier Universitaire D' Amiens - Godefroy, Olivier
dc.contributor.affiliationUniversity of Helsinki - Jokinen, Hanna
dc.contributor.affiliationLeiden University Medical Center - Mahinrad, Simin
dc.contributor.affiliationSeoul National University Bundang Hospital - Bae, Hee-Joon
dc.contributor.affiliationMaastricht University - Köhler, Sebastian
dc.contributor.affiliationMaastricht University - Douven, Elles
dc.contributor.affiliationMaastricht University Medical Centre - Staals, Julie
dc.contributor.affiliationNational University of Singapore - Chen, Christopher
dc.contributor.affiliationNational University of Singapore - Xu, Xin
dc.contributor.affiliationNational University of Singapore - Chong, Eddie J
dc.contributor.affiliationUniversity of Ibadan - Akinyemi, Rufus O
dc.contributor.affiliationNewcastle University - Kalaria, Rajesh N
dc.contributor.affiliationUniversity of Ibadan - Ogunniyi, Adesola
dc.contributor.affiliationCentre Hospitalier Universitaire D' Amiens - Barbay, Mélanie
dc.contributor.affiliationCentre Hospitalier Universitaire D' Amiens - Roussel, Martine
dc.contributor.affiliationHallym University Sacred Heart Hospital - Lee, Byung-Chul
dc.contributor.affiliationMonash University - Srikanth, Velandai K
dc.contributor.affiliationMonash University - Moran, Christopher
dc.contributor.affiliationNational Neuroscience Institute - Kandiah, Nagaendran
dc.contributor.affiliationUniversity of New South Wales - Chander, Russell J
dc.contributor.affiliationNorthwestern University - Sabayan, Behnam
dc.contributor.affiliationLeiden University Medical Center - Jukema, J. Wouter
dc.contributor.affiliationUniversity of Helsinki - Melkas, Susanna
dc.contributor.affiliationUniversity of Helsinki - Erkinjuntti, Timo
dc.contributor.affiliationUniversity of New South Wales - Brodaty, Henry
dc.contributor.affiliationUniversity of Lille - Bordet, Régis
dc.contributor.affiliationUniversity of Lille - Bombois, Stéphanie
dc.contributor.affiliationUniversity of Lille - Hénon, Hilde
dc.contributor.affiliationUniversity of New South Wales - Lipnicki, Darren M
dc.contributor.affiliationUniversity of New South Wales - Kochan, Nicole A
dc.contributor.affiliationHallym University Sacred Heart Hospital - Lim, Jae-Sung
dc.contributor.affiliationUniversity of New South Wales - Sachdev, Perminder S
dc.contributor.authorLo, Jessica W
dc.contributor.authorCrawford, John D
dc.contributor.authorDesmond, David W
dc.contributor.authorGodefroy, Olivier
dc.contributor.authorJokinen, Hanna
dc.contributor.authorMahinrad, Simin
dc.contributor.authorBae, Hee-Joon
dc.contributor.authorKöhler, Sebastian
dc.contributor.authorDouven, Elles
dc.contributor.authorStaals, Julie
dc.contributor.authorChen, Christopher
dc.contributor.authorXu, Xin
dc.contributor.authorChong, Eddie J
dc.contributor.authorAkinyemi, Rufus O
dc.contributor.authorKalaria, Rajesh N
dc.contributor.authorOgunniyi, Adesola
dc.contributor.authorBarbay, Mélanie
dc.contributor.authorRoussel, Martine
dc.contributor.authorLee, Byung-Chul
dc.contributor.authorSrikanth, Velandai K
dc.contributor.authorMoran, Christopher
dc.contributor.authorKandiah, Nagaendran
dc.contributor.authorChander, Russell J
dc.contributor.authorSabayan, Behnam
dc.contributor.authorJukema, J. Wouter
dc.contributor.authorMelkas, Susanna
dc.contributor.authorErkinjuntti, Timo
dc.contributor.authorBrodaty, Henry
dc.contributor.authorBordet, Régis
dc.contributor.authorBombois, Stéphanie
dc.contributor.authorHénon, Hilde
dc.contributor.authorLipnicki, Darren M
dc.contributor.authorKochan, Nicole A
dc.contributor.authorLim, Jae-Sung
dc.contributor.authorSachdev, Perminder S
dc.coverage.spatialUSA
dc.coverage.spatialAsia
dc.coverage.spatialEurope
dc.coverage.spatialAfrica
dc.coverage.spatialAustralia
dc.date.accessioned2025-03-24T15:21:20Z
dc.date.issued2019-11-12
dc.date.issued2019-11-12
dc.descriptionOBJECTIVE: To address the variability in prevalence estimates and inconsistencies in potential risk factors for post-stroke cognitive impairment (PSCI) using a standardised approach and individual participant data (IPD) from international cohorts in the STROKOG consortium. METHODS: We harmonised data from thirteen studies based in eight countries. Neuropsychological test scores 2 to 6 months after stroke or TIA and appropriate normative data were used to calculate standardised cognitive domain scores. Domain-specific impairment was based on percentile cut-offs from normative groups, and associations between domain scores and risk factors were examined using one-stage IPD meta-analysis. RESULTS: In a combined sample of 3,146 participants admitted to hospital for stroke (97%) or TIA (3%), 44% were impaired in global cognition and 30–35% in individual domains 2 to 6 months after the index event. Diabetes and a history of past stroke were strongly associated with poorer cognitive function after covariate adjustments; hypertension, smoking and atrial fibrillation had weaker domain-specific associations. While there were no significant differences in domain impairment among ethno-racial groups, some inter-ethnic differences were found in the effects of risk factors on cognition. CONCLUSIONS: This paper confirms the high prevalence of PSCI in diverse populations, highlights common risk factors, in particular diabetes, and points to ethno-racial differences which warrant attention in the development of prevention strategies.
dc.identifierhttps://doi.org/10.5061/dryad.m517990
dc.identifier.urihttps://hydatakatalogi-test-24.it.helsinki.fi/handle/123456789/10850
dc.rightsOpen
dc.rights.licensecc-zero
dc.subjectVascular dementia
dc.subjectconsortium
dc.subjectpost-stroke cognitive impairment
dc.subjectDementia
dc.titleData from: Profile of and risk factors for post-stroke cognitive impairment in diverse ethno-regional groups
dc.typedataset
dc.typedataset

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