Genetic insight into a polygenic trait using a novel Genome Wide Association approach in a wild amphibian population
No Thumbnail Available
Restricted Availability
Date
2024-03-21, 2024-03-21
Persistent identifier of the Data Catalogue metadata
Creator/contributor
Editor
Journal title
Journal volume
Publisher
Publication Type
dataset
dataset
dataset
Peer Review Status
Repositories
Access rights
Open
ISBN
ISSN
Description
Body size variation is central in the evolution of life history traits in amphibians, but the underlying genetic architecture of this complex trait is still largely unknown. Herein, we studied the genetic basis of body size and fecundity of the alternative morphotypes in a wild population of the Greek smooth newt (Lissotriton graecus). By combining a Genome-wide association approach with linkage disequilibrium network analysis, we were able to identify clusters of highly correlated loci thus maximizing sequence data for downstream analysis. The putatively associated variants explained 12.8% to 44.5% of the total phenotypic variation in body size and were mapped to genes with functional roles in the regulation of gene expression and cell cycle processes. Our study is the first to provide insights into the genetic basis of complex traits in newts and provides a useful tool to identify loci potentially involved in fitness related traits in small data sets from natural populations in non-model species.
Link to original dataset
Keyword (yso)
Keyword
Linkage disequilibrium, Network analysis, Body size, Fitness, newts