Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations

dc.contributor.affiliationUniversity of Helsinki - Simola, Jaana
dc.contributor.affiliationUniversity of Helsinki - Siebenhühner, Felix
dc.contributor.affiliationAalto University - Myrov, Vladislav
dc.contributor.affiliationUniversity of Helsinki - Kantojärvi, Katri
dc.contributor.affiliationUniversity of Helsinki - Paunio, Tiina
dc.contributor.affiliationAalto University - Palva, J. Matias
dc.contributor.affiliationAarhus University - Brattico, Elvira
dc.contributor.affiliationUniversity of Helsinki - Palva, Satu
dc.contributor.authorSimola, Jaana
dc.contributor.authorSiebenhühner, Felix
dc.contributor.authorMyrov, Vladislav
dc.contributor.authorKantojärvi, Katri
dc.contributor.authorPaunio, Tiina
dc.contributor.authorPalva, J. Matias
dc.contributor.authorBrattico, Elvira
dc.contributor.authorPalva, Satu
dc.date.accessioned2025-03-24T15:11:15Z
dc.date.issued2023-01-17
dc.date.issued2023-01-17
dc.descriptionNeuronal oscillations, their inter-areal synchronization, and scale-free dynamics constitute fundamental mechanisms for cognition by regulating communication in neuronal networks. These oscillatory dynamics have large inter-individual variability that is partly heritable. We hypothesized that this variability could be partially explained by genetic polymorphism in neuromodulatory genes. We recorded resting-state magnetoencephalography (MEG) from 82 healthy participants and investigated whether oscillation dynamics were influenced by genetic polymorphisms in Catechol-O-methyltransferase (COMT) Val158Met and brain-derived neurotrophic factor (BDNF) Val66Met. Both COMT and BDNF polymorphisms influenced local oscillation amplitudes and their long-range temporal correlations (LRTCs), while only BDNF polymorphism affected the strength of large-scale synchronization. Our findings demonstrate that COMT and BDNF genetic polymorphisms contribute to inter-individual variability in neuronal oscillation dynamics. Comparison of these results to computational modeling of near-critical synchronization dynamics further suggested that COMT and BDNF polymorphisms influenced local oscillations by modulating the excitation-inhibition balance according to the brain criticality framework.
dc.identifierhttps://doi.org/10.5061/dryad.3n5tb2rjp
dc.identifier.urihttps://hydatakatalogi-test-24.it.helsinki.fi/handle/123456789/9052
dc.rightsOpen
dc.rights.licensecc-zero
dc.subjectmagnetoencephalography
dc.titleGenetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations
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