Data from: Genetic rescue of an endangered domestic animal through outcrossing with closely related breeds: a case study of the Norwegian Lundehund

dc.contributor.affiliationAalborg University - Stronen, Astrid V.
dc.contributor.affiliationUniversity of Helsinki - Salmela, Elina
dc.contributor.affiliationIcelandic Genetic Resource Center, Hvanneyri, Borganes, Iceland* - Baldursdóttir, BK
dc.contributor.affiliationNordic Genetic Resource Center, Ås, Norway* - Berg, P
dc.contributor.affiliationNorwegian Lundehund Club, Tangen, Trondheim, Norway* - Espelien, IS
dc.contributor.affiliationUniversity of Helsinki - Järvi, Kirsi
dc.contributor.affiliationNorwegian University of Science and Technology - Jensen, Henrik
dc.contributor.affiliationAalborg University - Kristensen, TN
dc.contributor.affiliationNorwegian University of Science and Technology - Melis, Claudia
dc.contributor.affiliationAarhus University - Manenti, Tommaso
dc.contributor.affiliationUniversity of Helsinki - Lohi, Hannes
dc.contributor.affiliationAalborg University - Pertoldi, Cino
dc.contributor.affiliationAarhus University - Kristensen, Torsten N.
dc.contributor.authorStronen, Astrid V.
dc.contributor.authorSalmela, Elina
dc.contributor.authorBaldursdóttir, BK
dc.contributor.authorBerg, P
dc.contributor.authorEspelien, IS
dc.contributor.authorJärvi, Kirsi
dc.contributor.authorJensen, Henrik
dc.contributor.authorKristensen, TN
dc.contributor.authorMelis, Claudia
dc.contributor.authorManenti, Tommaso
dc.contributor.authorLohi, Hannes
dc.contributor.authorPertoldi, Cino
dc.contributor.authorKristensen, Torsten N.
dc.date.accessioned2025-03-24T15:18:54Z
dc.date.issued2017-06-06
dc.date.issued2017-06-06
dc.descriptionGenetic rescue, outcrossing with individuals from a related population, is used to augment genetic diversity in populations threatened by severe inbreeding and extinction. The endangered Norwegian Lundehund dog (henceforth Lundehund) underwent at least two severe bottlenecks in the 1940s and 1960s that each left only five inbred dogs, and the approximately 1500 dogs remaining world-wide today appear to descend from only two individuals. The Lundehund has a high prevalence of a gastrointestinal disease, to which all remaining dogs may be predisposed. Outcrossing is currently performed with three Nordic Spitz breeds: Norwegian Buhund, Icelandic Sheepdog, and Norrbottenspets. Examination of single nucleotide polymorphism (SNP) genotypes based on 165K loci in 48 dogs from the four breeds revealed substantially lower genetic diversity for the Lundehund (HE 0.035) than for other breeds (HE 0.209-0.284). Analyses of genetic structure with 16K linkage disequilibrium-pruned SNPs showed four distinct genetic clusters. Pairwise FST values between Lundehund and the candidate breeds were highest for Icelandic Sheepdog, followed by Buhund and Norrbottenspets. We assessed the presence of outlier loci among candidate breeds and examined flanking genome regions (1 megabase) for genes under possible selection to identify potential adaptive differences among breeds; outliers were observed in flanking regions of genes associated with key functions including the immune system, metabolism, cognition and physical development. We suggest crossbreeding with multiple breeds as the best strategy to increase genetic diversity for the Lundehund and reduce the incidence of health problems. For this project, the three candidate breeds were first selected based on phenotypes and then subject to genetic investigation. Because phenotypes are often paramount for domestic breed owners, such a strategy could provide a helpful approach for genetic rescue and restoration of other domestic populations at risk, by ensuring the involvement of owners, breeders and managers at the start of the project.
dc.identifierhttps://doi.org/10.5061/dryad.5gm12
dc.identifier.urihttps://hydatakatalogi-test-24.it.helsinki.fi/handle/123456789/10257
dc.rightsOpen
dc.rights.licensecc-zero
dc.subjectoutlier loci
dc.subjectCanis lupus familiaris
dc.subjectsingle nucleotide polymorphism
dc.subjectInbreeding
dc.titleData from: Genetic rescue of an endangered domestic animal through outcrossing with closely related breeds: a case study of the Norwegian Lundehund
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