Data from: The shepherds' tale: a genome-wide study across 9 dog breeds implicates two loci in the regulation of fructosamine serum concentration in Belgian shepherds

dc.contributor.affiliationSwedish University of Agricultural Sciences - Forsberg, Simon K. G.
dc.contributor.affiliationSwedish University of Agricultural Sciences - Kierczak, Marcin
dc.contributor.affiliationSwedish University of Agricultural Sciences - Ljungvall, Ingrid
dc.contributor.affiliationUniversity of Liège - Merveille, Anne-Christine
dc.contributor.affiliationUniversity of Helsinki - Wiberg, Maria
dc.contributor.affiliationUniversity of Copenhagen - Willesen, Jakob Lundgren
dc.contributor.affiliationSwedish University of Agricultural Sciences - Hanås, Sofia
dc.contributor.affiliationUniversity of Liège - Lequarré, Anne-Sophie
dc.contributor.affiliationUniversity of Copenhagen - Sørensen, Louise Mejer
dc.contributor.affiliationFrench National Institute for Agricultural Research - Tiret, Laurent
dc.contributor.affiliationUniversity of Liège - McEntee, Kathleen
dc.contributor.affiliationUniversity of Helsinki - Seppälä, Eija
dc.contributor.affiliationUniversity of Copenhagen - Koch, Jørgen
dc.contributor.affiliationUniversity of Liège - Battaille, Géraldine
dc.contributor.affiliationUniversity of Helsinki - Lohi, Hannes
dc.contributor.affiliationUniversity of Copenhagen - Fredholm, Merete
dc.contributor.affiliationSwedish University of Agricultural Sciences - Häggström, Jens
dc.contributor.affiliationSwedish University of Agricultural Sciences - Carlborg, Örjan
dc.contributor.affiliationUppsala University - Lindblad-Toh, Kerstin
dc.contributor.affiliationSwedish University of Agricultural Sciences - Höglund, Katja
dc.contributor.authorForsberg, Simon K. G.
dc.contributor.authorKierczak, Marcin
dc.contributor.authorLjungvall, Ingrid
dc.contributor.authorMerveille, Anne-Christine
dc.contributor.authorGouni, Vassiliki
dc.contributor.authorWiberg, Maria
dc.contributor.authorWillesen, Jakob Lundgren
dc.contributor.authorHanås, Sofia
dc.contributor.authorLequarré, Anne-Sophie
dc.contributor.authorSørensen, Louise Mejer
dc.contributor.authorTiret, Laurent
dc.contributor.authorMcEntee, Kathleen
dc.contributor.authorSeppälä, Eija
dc.contributor.authorKoch, Jørgen
dc.contributor.authorBattaille, Géraldine
dc.contributor.authorLohi, Hannes
dc.contributor.authorFredholm, Merete
dc.contributor.authorChetboul, Valerie
dc.contributor.authorHäggström, Jens
dc.contributor.authorCarlborg, Örjan
dc.contributor.authorLindblad-Toh, Kerstin
dc.contributor.authorHöglund, Katja
dc.coverage.spatialSweden
dc.coverage.spatialBelgium
dc.coverage.spatialFinland
dc.coverage.spatialDenmark
dc.coverage.spatialFrance
dc.date.accessioned2025-03-24T15:21:31Z
dc.date.issued2016-04-28
dc.date.issued2016-04-28
dc.descriptionDiabetes mellitus is a serious health problem in both dogs and humans. Certain dog breeds show high prevalence of the disease, whereas other breeds are at low risk. Fructosamine and glycated hemoglobin (HbA1c) are two major biomarkers of glycaemia where serum concentrations reflect glucose turnover over the past few weeks to months. In this study, we searched for genetic factors influencing variation in serum fructosamine concentration in healthy dogs using data from nine dog breeds. Considering all breeds together, we did not find any genome-wide significant associations to fructosamine serum concentration. However, by performing breed-specific analyses we revealed an association on CFA 3 (pcorrected ≈ 1.68 × 10−6) in Belgian shepherd dogs. The associated region and its close neighborhood harbours interesting candidate genes such as LETM1 and GAPDH that are important in glucose metabolism and have previously been implicated in the aetiology of diabetes mellitus. To further explore the genetics of this breed specificity, we screened the genome for reduced heterozygosity stretches private to the Belgian shepherd breed. This revealed a region with reduced heterozygosity that shows a statistically significant interaction (p = 0.025) with the association region on CFA3. This region also harbours some interesting candidate genes and regulatory regions but the exact mechanisms underlying the interaction are still unknown. Nevertheless, this finding provides a plausible explanation for breed-specific genetic effects for complex traits in dogs. Shepherd breeds are at low risk of developing diabetes mellitus. The findings in Belgian shepherds could be connected to a protective mechanism against the disease. Further insight into the regulation of glucose metabolism could improve diagnostic and therapeutic methods for diabetes mellitus.
dc.identifierhttps://doi.org/10.5061/dryad.ft6fv
dc.identifier.urihttps://hydatakatalogi-test-24.it.helsinki.fi/handle/123456789/10939
dc.rightsOpen
dc.rights.licensecc-zero
dc.subjectbreed specific sweep
dc.subjectepistasis
dc.subjectCanis lupus familiaris
dc.subjectfructosamine
dc.subjectgene-gene interaction
dc.subjectdiabetes
dc.subjectBelgian shepherd
dc.subjectbreed
dc.titleData from: The shepherds' tale: a genome-wide study across 9 dog breeds implicates two loci in the regulation of fructosamine serum concentration in Belgian shepherds
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