A Curated Gene and Biological System Annotation of Adverse Outcome Pathways Related to Human Health

dc.contributor.affiliationFinnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland - Saarimäki, Laura Aliisa
dc.contributor.affiliationFinnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland - Fratello, Michele
dc.contributor.affiliationFinnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland - Pavel, Alisa
dc.contributor.affiliationFinnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland - Korpilähde, Seela
dc.contributor.affiliationFinnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland - Leppänen, Jenni
dc.contributor.affiliationFinnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Tampere Institute of Advanced Studies, Tampere University, Tampere, Finland - Serra, Angela
dc.contributor.affiliationFinnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Institute of Biotechnology, HiLife, University of Helsinki, Helsinki, Finland - Greco, Dario
dc.contributor.authorSaarimäki, Laura Aliisa
dc.contributor.authorFratello, Michele
dc.contributor.authorPavel, Alisa
dc.contributor.authorKorpilähde, Seela
dc.contributor.authorLeppänen, Jenni
dc.contributor.authorSerra, Angela
dc.contributor.authorGreco, Dario
dc.date.accessioned2025-03-24T15:26:25Z
dc.date.issued2022-11-01
dc.date.issued2022-11-01
dc.descriptionAdverse Outcome Pathways (AOPs) are multi-scale models of biological mechanisms connecting molecular initiating events to adverse outcomes through measurable key events. AOPs can guide the use and development of new approach methodologies (NAMs) aimed at reducing animal experimentation in chemical safety assessment. Here, we present a comprehensive molecular annotation of AOPs relevant to human health to embed the AOP framework into molecular data interpretation, which supports the development and application of novel AOP-based approaches in biomedical research. Please cite the following publication alongside this Zenodo entry when using the data: Saarimäki, L.A., Fratello, M., Pavel, A. et al. A curated gene and biological system annotation of adverse outcome pathways related to human health. Sci Data 10, 409 (2023). https://doi.org/10.1038/s41597-023-02321-w
dc.identifierhttps://doi.org/10.5281/zenodo.7980953
dc.identifier.urihttps://hydatakatalogi-test-24.it.helsinki.fi/handle/123456789/11407
dc.rightsOpen
dc.rights.licensecc-by-4.0
dc.subjectAdverse Outcome Pathways
dc.subjectToxicology
dc.subjectAnnotation
dc.titleA Curated Gene and Biological System Annotation of Adverse Outcome Pathways Related to Human Health
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