drugcomb_oct2019_withdoses
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2021-05-29, 2021-05-29
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Description
Columns are:
"block_id"|"drug_row"|"drug_col"|"drug_row_cid"|"drug_col_cid"|"conc_r"|"conc_c"|"inhibition"|"synergy_zip"|"synergy_bliss"|"synergy_loewe"|"synergy_hsa"|"cell_line_name"|"css_ri".
* block_id refers to one experiment, that is testing two drugs in different doses in a single cell line. Biological replicates have different block_ids
* drug_row and drug_col are commonly used drug names
* drug_row_cid and drug_col_cid are CID drug identifiers
* conc_c and conc_r are drug doses in uM
* inhibition refers to percent growth inhibition as measured using a CTG cell viability assay (in most cases)
* four synergy scores are calculated using distinct four null models. For further info please refer to Zagidullin 2019 in Nucleic Acids Research
* CSS_RI is a combination sensitivity score, for more info refer to Malyutina 2019 in PLoS computational biology