Data from: Epigenome-wide association study of lung function level and its change

dc.contributor.affiliationSwiss Tropical and Public Health Institute - Imboden, Medea
dc.contributor.affiliationPublic Health England - Wielscher, Matthias
dc.contributor.affiliationUniversity of Southampton - Rezwan, Faisal I
dc.contributor.affiliationPublic Health England - Amaral, Andre F S
dc.contributor.affiliationSwiss Tropical and Public Health Institute - Schaffner, Emmanuel
dc.contributor.affiliationSwiss Tropical and Public Health Institute - Jeong, Ayoung
dc.contributor.affiliationSwiss Tropical and Public Health Institute - Beckmeyer-Borowko, Anna
dc.contributor.affiliationUniversity of Edinburgh - Harris, Sarah E
dc.contributor.affiliationUniversity of Edinburgh - Starr, John M
dc.contributor.affiliationUniversity of Edinburgh - Deary, Ian J
dc.contributor.affiliationHelmholtz Zentrum München - Flexeder, Claudia
dc.contributor.affiliationHelmholtz Zentrum München - Waldenberger, Melanie
dc.contributor.affiliationHelmholtz Zentrum München - Peters, Annette
dc.contributor.affiliationHelmholtz Zentrum München - Schulz, Holger
dc.contributor.affiliationUniversity of Memphis - Chen, Su
dc.contributor.affiliationUniversity of Memphis - Sunny, Shadia KHan
dc.contributor.affiliationUniversity of Memphis - Karmaus, Wilfried J J
dc.contributor.affiliationUniversity of Memphis - Jiang, Yu
dc.contributor.affiliationUniversity of Innsbruck - Erhart, Gertraud
dc.contributor.affiliationUniversity of Innsbruck - Kronenberg, Florian
dc.contributor.affiliationUniversity of Bristol - Arathimos, Ryan
dc.contributor.affiliationUniversity of Bristol - Sharp, Gemma C
dc.contributor.affiliationUniversity of Bristol - Henderson, Alexander John
dc.contributor.affiliationInstitute for Molecular Medicine Finland - Fu, Yu
dc.contributor.affiliationUniversity of Helsinki - Piirila, Paivi
dc.contributor.affiliationUniversity of Helsinki - Pietilainen, Kirsi H
dc.contributor.affiliationInstitute for Molecular Medicine Finland - Ollikainen, Miina
dc.contributor.affiliationScience for Life Laboratory - Johannson, Asa
dc.contributor.affiliationScience for Life Laboratory - Gyllensten, Ulf
dc.contributor.affiliationUniversity Medical Center Groningen - de Vries, Maaike
dc.contributor.affiliationUniversity Medical Center Groningen - van der Plaat, Diana
dc.contributor.affiliationUniversity Medical Center Groningen - de Jong, Kim
dc.contributor.affiliationUniversity of Nottingham - Hall, Ian P
dc.contributor.affiliationUniversity of Leicester - Tobin, Martin D
dc.contributor.affiliationUniversity of Southampton - Holloway, John W
dc.contributor.affiliationPublic Health England - Jarvis, Deborah
dc.contributor.affiliationSwiss Tropical and Public Health Institute - Probst-Hensch, Nicole M
dc.contributor.authorImboden, Medea
dc.contributor.authorWielscher, Matthias
dc.contributor.authorRezwan, Faisal I
dc.contributor.authorAmaral, Andre F S
dc.contributor.authorSchaffner, Emmanuel
dc.contributor.authorJeong, Ayoung
dc.contributor.authorBeckmeyer-Borowko, Anna
dc.contributor.authorHarris, Sarah E
dc.contributor.authorStarr, John M
dc.contributor.authorDeary, Ian J
dc.contributor.authorFlexeder, Claudia
dc.contributor.authorWaldenberger, Melanie
dc.contributor.authorPeters, Annette
dc.contributor.authorSchulz, Holger
dc.contributor.authorChen, Su
dc.contributor.authorSunny, Shadia KHan
dc.contributor.authorKarmaus, Wilfried J J
dc.contributor.authorJiang, Yu
dc.contributor.authorErhart, Gertraud
dc.contributor.authorKronenberg, Florian
dc.contributor.authorArathimos, Ryan
dc.contributor.authorSharp, Gemma C
dc.contributor.authorHenderson, Alexander John
dc.contributor.authorFu, Yu
dc.contributor.authorPiirila, Paivi
dc.contributor.authorPietilainen, Kirsi H
dc.contributor.authorOllikainen, Miina
dc.contributor.authorJohannson, Asa
dc.contributor.authorGyllensten, Ulf
dc.contributor.authorde Vries, Maaike
dc.contributor.authorvan der Plaat, Diana
dc.contributor.authorde Jong, Kim
dc.contributor.authorBoezen, Hendrika M
dc.contributor.authorHall, Ian P
dc.contributor.authorTobin, Martin D
dc.contributor.authorJärvelin, Marjo-Riitta
dc.contributor.authorHolloway, John W
dc.contributor.authorJarvis, Deborah
dc.contributor.authorProbst-Hensch, Nicole M
dc.coverage.spatialEUROPE
dc.coverage.spatialEurope
dc.date.accessioned2025-03-24T15:23:17Z
dc.date.issued2019-06-06
dc.date.issued2019-06-06
dc.descriptionPrevious reports link differential DNA methylation (DNAme) to environmental exposures which are associated with lung function. Direct evidence on lung function DNAme is however limited. We undertook an agnostic epigenome-wide association study (EWAS) on pre-bronchodilation lung function and its change in adults. In a discovery-replication EWAS design, DNAme in blood and spirometry were measured twice, six-to-15 years apart, in the same participants of three adult population-based discovery cohorts (n=2,043). Associated DNAme markers (P<5x10-7) were tested in seven replication cohorts (adult: n=3,327; childhood: n=420). Technical-bias adjusted residuals of a regression of the normalized absolute beta-values on control-probe-derived principle components were regressed on level and change of FEV1, FEV1/FVC and FVC in covariate-adjusted discovery EWAS. Inverse-variance weighted meta-analyses were performed on results from discovery and replication samples in all participants and never smokers. EWAS signals were enriched for smoking-related DNAme. We replicated 57 lung function DNAme in adult, but not childhood samples, all previously associated with smoking. Markers not previously associated with smoking failed replication. cg05575921 (AHRR) showed the statistically most significant association with cross-sectional lung function (FEV1/FVC: Pdiscovery=3.96x10-21 and Pcombined=7.22x10-50). A score combining ten DNAme markers previously reported to mediate the smoking effect on lung function was associated with lung function (FEV1/FVC: P=2.65x10-20). Our results reveal that lung function associated methylation signals in adults are predominantly smoking-related and possibly of clinical utility in identifying poor lung function and accelerated decline. Larger studies with more repeat time points are needed to identify lung function DNAme in never smokers and in children.
dc.identifierhttps://doi.org/10.5061/dryad.pr10c20
dc.identifier.urihttps://hydatakatalogi-test-24.it.helsinki.fi/handle/123456789/11075
dc.rightsOpen
dc.rights.licensecc-zero
dc.subjectgenome-wide
dc.subjectlung function
dc.subjectSmoking
dc.subjectHomo Sapiens
dc.subjectepigenetics
dc.titleData from: Epigenome-wide association study of lung function level and its change
dc.typedataset
dc.typedataset
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