Contribution of allelic imbalance to colorectal cancer

dc.contributor.affiliationUniversity of Helsinki - Palin, Kimmo
dc.contributor.affiliationUniversity of Helsinki - Pitkänen, Esa
dc.contributor.affiliationUniversity of Helsinki - Turunen, Mikko
dc.contributor.affiliationUniversity of Helsinki - Sahu, Biswajyoti
dc.contributor.affiliationUniversity of Helsinki - Pihlajamaa, Päivi
dc.contributor.affiliationUniversity of Helsinki - Kivioja, Teemu
dc.contributor.affiliationKarolinska Institute - Kaasinen, Eevi
dc.contributor.affiliationUniversity of Helsinki - Välimäki, Niko
dc.contributor.affiliationUniversity of Helsinki - Hänninen, Ulrika
dc.contributor.affiliationUniversity of Helsinki - Cajuso, Tatiana
dc.contributor.affiliationUniversity of Helsinki - Aavikko, Mervi
dc.contributor.affiliationUniversity of Helsinki - Tuupanen, Sari
dc.contributor.affiliationUniversity of Helsinki - Kilpivaara, Outi
dc.contributor.affiliationUniversity of Helsinki - van den Berg, Linda
dc.contributor.affiliationUniversity of Helsinki - Kondelin, Johanna
dc.contributor.affiliationUniversity of Helsinki - Tanskanen, Tomas
dc.contributor.affiliationUniversity of Helsinki - Katainen, Riku
dc.contributor.affiliationUniversity of Helsinki - Grau, Marta
dc.contributor.affiliationUniversity of Helsinki - Rauanheimo, Heli
dc.contributor.affiliationUniversity of Helsinki - Plaketti, Roosa-Maria
dc.contributor.affiliationUniversity of Helsinki - Taira, Aurora
dc.contributor.affiliationUniversity of Helsinki - Sulo, Päivi
dc.contributor.affiliationUniversity of Helsinki - Hartonen, Tuomo
dc.contributor.affiliationKarolinska Institute - Dave, Kashyap
dc.contributor.affiliationKarolinska Institute - Schmierer, Bernhard
dc.contributor.affiliationKarolinska Institute - Botla, Sandeep
dc.contributor.affiliationUniversity of Helsinki - Sokolova, Maria
dc.contributor.affiliationUniversity of Helsinki - Vähärautio, Anna
dc.contributor.affiliationUniversity of Helsinki - Gladysz, Kornelia
dc.contributor.affiliationUniversity of Geneva - Ongen, Halit
dc.contributor.affiliationUniversity of Geneva - Dermitzakis, Emmanouil
dc.contributor.affiliationAarhus University Hospital - Bramsen, Jesper
dc.contributor.affiliationAarhus University Hospital - Ørntoft, Torben
dc.contributor.affiliationAarhus University Hospital - Lindbjerg Andersen, Claus
dc.contributor.affiliationUniversity of Helsinki - Ristimäki, Ari
dc.contributor.affiliationHelsinki University Hospital - Lepistö, Anna
dc.contributor.affiliationHelsinki University Hospital - Renkonen-Sinisalo, Laura
dc.contributor.affiliationJyväskylä Central Hospital and University of Eastern Finland - Mecklin, Jukka-Pekka
dc.contributor.affiliationUniversity of Helsinki, Karolinska Institute - Taipale, Jussi
dc.contributor.affiliationUniversity of Helsinki - Aaltonen, Lauri
dc.contributor.authorPalin, Kimmo
dc.contributor.authorPitkänen, Esa
dc.contributor.authorTurunen, Mikko
dc.contributor.authorSahu, Biswajyoti
dc.contributor.authorPihlajamaa, Päivi
dc.contributor.authorKivioja, Teemu
dc.contributor.authorKaasinen, Eevi
dc.contributor.authorVälimäki, Niko
dc.contributor.authorHänninen, Ulrika
dc.contributor.authorCajuso, Tatiana
dc.contributor.authorAavikko, Mervi
dc.contributor.authorTuupanen, Sari
dc.contributor.authorKilpivaara, Outi
dc.contributor.authorvan den Berg, Linda
dc.contributor.authorKondelin, Johanna
dc.contributor.authorTanskanen, Tomas
dc.contributor.authorKatainen, Riku
dc.contributor.authorGrau, Marta
dc.contributor.authorRauanheimo, Heli
dc.contributor.authorPlaketti, Roosa-Maria
dc.contributor.authorTaira, Aurora
dc.contributor.authorSulo, Päivi
dc.contributor.authorHartonen, Tuomo
dc.contributor.authorDave, Kashyap
dc.contributor.authorSchmierer, Bernhard
dc.contributor.authorBotla, Sandeep
dc.contributor.authorSokolova, Maria
dc.contributor.authorVähärautio, Anna
dc.contributor.authorGladysz, Kornelia
dc.contributor.authorOngen, Halit
dc.contributor.authorDermitzakis, Emmanouil
dc.contributor.authorBramsen, Jesper
dc.contributor.authorØrntoft, Torben
dc.contributor.authorLindbjerg Andersen, Claus
dc.contributor.authorRistimäki, Ari
dc.contributor.authorLepistö, Anna
dc.contributor.authorRenkonen-Sinisalo, Laura
dc.contributor.authorMecklin, Jukka-Pekka
dc.contributor.authorTaipale, Jussi
dc.contributor.authorAaltonen, Lauri
dc.date.accessioned2025-03-24T15:11:47Z
dc.date.issued2018-09-10
dc.date.issued2018-09-10
dc.descriptionPoint mutations in cancer have been extensively studied but chromosomal gains and losses have been more challenging to interpret due to their unspecific nature. Here we examine high-resolution allelic imbalance (AI) landscape in 1699 colorectal cancers, 256 of which have been whole genome sequenced (WGSed). The imbalances pinpoint 38 genes as plausible AI targets based on previous knowledge, and unbiased CRISPR-Cas9 knockout and activation screens identified altogether 79 genes within AI peaks regulating cell growth. Genetic and functional data implicates loss of TP53 as a sufficient driver of AI. The WGS highlights an influence of copy number aberrations on the rate of detected somatic point mutations. Importantly, the data reveal several associations between AI target genes, suggesting a role for a network of lineage-determining transcription factors in colorectal tumorigenesis. Overall, the results unravel the contribution of AI in colorectal cancer and provide a plausible explanation why so few genes are commonly affected by point mutations in cancers.
dc.identifierhttps://doi.org/10.5281/zenodo.1222172
dc.identifier.urihttps://hydatakatalogi-test-24.it.helsinki.fi/handle/123456789/9360
dc.rightsOpen
dc.rights.licensecc-by-sa-4.0
dc.titleContribution of allelic imbalance to colorectal cancer
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