Data from: Positive cytoplasmic UCHL5 tumor expression in gastric cancer is linked to improved prognosis

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dc.contributor.affiliationUniversity of Helsinki - Arpalahti, Leena
dc.contributor.affiliationUniversity of Helsinki - Laitinen, Alli
dc.contributor.affiliationUniversity of Helsinki - Hagström, Jaana
dc.contributor.affiliationUniversity of Helsinki - Mustonen, Harri
dc.contributor.affiliationUniversity of Helsinki - Kokkola, Arto
dc.contributor.affiliationUniversity of Helsinki - Böckelman, Camilla
dc.contributor.affiliationUniversity of Helsinki - Haglund, Caj
dc.contributor.affiliationUniversity of Helsinki - Holmberg, Carina I.
dc.contributor.authorArpalahti, Leena
dc.contributor.authorLaitinen, Alli
dc.contributor.authorHagström, Jaana
dc.contributor.authorMustonen, Harri
dc.contributor.authorKokkola, Arto
dc.contributor.authorBöckelman, Camilla
dc.contributor.authorHaglund, Caj
dc.contributor.authorHolmberg, Carina I.
dc.date.accessioned2025-03-24T15:11:43Z
dc.date.issued2019-02-09
dc.date.issued2019-02-09
dc.descriptionGastric cancer is the second most common cause of cancer-related mortality worldwide. Accurate prediction of disease progression is difficult, and new biomarkers for clinical use are essential. Recently, we reported that the proteasome-associated deubiquitinating enzyme UCHL5/Uch37 is a new prognostic marker in both rectal cancer and pancreatic ductal adenocarcinoma. Here, we have assessed by immunohistochemistry UCHL5 tumor expression in gastric cancer. The study cohort comprised 650 patients, who underwent surgery in Helsinki University Hospital, Finland, between 1983 and 2009. We investigated the association of cytoplasmic UCHL5 tumor expression to assess clinicopathological parameters and patient survival. Positive cytoplasmic UCHL5 tumor immunoexpression is linked to increased survival of patients with small (<5 cm) tumors (p = 0.001), disease stages I-II (p = 0.025), and age 66 years or older (p = 0.037). UCHL5 is thus a potential marker in gastric cancer with new prognostic relevance.
dc.identifierhttps://doi.org/10.5061/dryad.89qr5
dc.identifier.urihttps://hydatakatalogi-test-24.it.helsinki.fi/handle/123456789/9333
dc.rightsOpen
dc.rights.licensecc-zero
dc.subjectproteasome
dc.subjectprognostic marker
dc.subjectgastric cancer
dc.subjectUCHL5
dc.titleData from: Positive cytoplasmic UCHL5 tumor expression in gastric cancer is linked to improved prognosis
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